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The Freiburg-based company eleva GmbH relies on laboratory autoclaves from Systec for the sterilization and inactivation of single-use bioreactor bags and reusable glass bioreactors. The in-house laboratory is currently focusing on the production of a drug candidate for the treatment of complement diseases based on moss cells. Due to the large quantities of bioreactor culture to be inactivated, they rely on the Systec HX-980 2D pass-through autoclave. The Systec pass-through autoclaves are specially designed for gas-tight installation in partition walls and are therefore equipped with two doors - to reliably maintain cleanroom conditions by separating clean and unclean areas.
Extensive sterilization requirements in the laboratory Cell culture technology
The cultivation of moss cells in bioreactors - the specialty of the company founded in 1999 under the name Greenovation - can generate large quantities of biological and GMO-containing waste. This includes bioreactor bags, which are difficult to autoclave due to their complex shape and composition. For example, it is necessary to precisely check the temperatures reached inside the bags during the autoclaving process, which the Systec HX-980 2D does easily using a flexible PT-100 temperature sensor.
Thanks to the particularly large usable volume of 1138 liters (980 liters nominal) of the autoclave purchased by the Freiburg laboratory, sterilization processes at eleva GmbH now take considerably less time. Thanks to the mobile loading trolley for convenient loading of large quantities of autoclave material and the easy-to-reach height of the Systec HX-980 2D, work processes are also considerably less time-consuming.
More flexibility than comparable solutions in the same volume category
When eleva GmbH decided to purchase an autoclave with the highest possible usable volume in 2019, it initially considered a number of wall-mounted and pass-through autoclaves from different manufacturers. The Systec HX series ultimately proved to be a much more cost-effective and flexible solution. Not least because of its greater mobility, the Systec pass-through autoclave was ultimately able to prevail over the alternatives on the market. Dr. Holger Niederkrüger, Head of Production at eleva GmbH, comments: "In my opinion, this autoclave series is a perfect fit for today's mostly flexible production machines installed on rollers in biopharmaceutical production."
Eleva GmbH also already uses a Systec V-series autoclave. Systec is proud to be able to support the innovative company with state-of-the-art autoclave solutions in the development of active ingredients based on moss cells.
Pictures: @eleva GmbH
